Metabolic engineering of Saccharomyces cerevisiae for ethanol and butanol biofuel production

Authors

  • Salman Khan Author
  • Asif Hussain Author
  • Muhammad Iftikhar Hussain Author
  • Sahibzada Muhammad Aqeel Author
  • Samra Basharat Author
  • Arif Hussain Author
  • Waleed Al-Ansi Author
  • Abdulqader Abdulqader Author
  • Nie Yao Author

Keywords:

strain robustness, biofuel, biomass, bio-butanol, nocked in, bio-ethanol, knocked out

Abstract

The production of biofuels through biological processes has garnered increasing attention due to their potential benefits over conventional fuels, including lower greenhouse gas emissions, higher energy output, and reduced-price fluctuations. However, the metabolic processes of primitive microorganisms used in biofuel production are not compatible with those of fossil fuels. To address this, scholars have employed metabolic engineering techniques to modify the metabolisms of various microorganisms, including S. cerevisiae, for enhanced biofuel production. Specifically, overexpression of enzymes involved in bioethanol and biobutanol production, knockouts of competing pathways, improvements in carbon flux and tolerance have been applied to maximize the potential of S. cerevisiae for bioethanol and biobutanol production. This review focuses on the current state of metabolic engineering of S. cerevisiae for the production of bioethanol from lignocellulose and biobutanol from all kind of substrates, along with the potential use of cell surface technology in this field.

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Published

2023-03-25

How to Cite

Khan, S., Hussain, A., Hussain, M. I., Aqeel, S. M., Basharat, S., Hussain, A., Al-Ansi, W., Abdulqader, A., & Yao, N. (2023). Metabolic engineering of Saccharomyces cerevisiae for ethanol and butanol biofuel production. International Journal of Environment, Agriculture and Biotechnology, 8(2). https://i.agriculturejournals.org/index.php/ijeab/article/view/141